Fata教授研究正常组织生物学和癌症。他的研究领域包括调节乳腺生物学的信号级联，乳腺癌/宫颈癌，植物来源的抗癌药物，以及宫颈病变的诊断成像。Fata教授也是纽约市立大学（CUNY）生物化学和生物学博士课程的教员。如果您有兴趣加入法塔博士的实验室，并对科学充满热情，并愿意为您的目标努力工作，请联系他。
度
博士，加拿大多伦多大学
加拿大圭尔夫大学理学士
Chaterjee， K., Mukherjee S., VanManen J., Banerjee P .和Fata JE.。膳食多酚、白藜芦醇和紫芪对人乳头状瘤病毒e6阳性宫颈癌模型的体外和体内抗肿瘤活性研究，中华肿瘤杂志，9(3),2019。
Senthilkumar HA, Fata JE, Kennelly EJ, Phytoestrogens: The current state of research emphasizing breast pathophysiology, Phytotherapy Research, 32(9):1707-1719 2018.
Chatterjee K, Al Sharif D, Mazza C, Syar P, Al Sharif M, Fata JE. Resveratrol and Pterostilbene Exhibit Anticancer Properties Involving the Downregulation of HPV Oncoprotein E6 in Cervical Cancer Cells. 10(2). pii: E243, Nutrients 2018.
Mukherjee S, Debata PR, Hussaini R, Chatterjee K, Baidoo JNE, Sampat S, Szerszen A, Navarra JP, Fata J, Severinova E, Banerjee P, Castellanos MR. Unique synergistic formulation of curcumin, epicatechin gallate and resveratrol, tricurin, suppresses HPV E6, eliminates HPV+ cancer cells, and inhibits tumor progression. Oncotarget. 8(37):60904-60916 2017
Li P, Anandhi Senthilkumar H, Figueroa M, Wu SB, Fata JE, Kennelly EJ, Long C. UPLC-QTOFMS(E)-Guided Dereplication of the Endangered Chinese Species Garcinia paucinervis to Identify Additional Benzophenone Derivatives. J Nat Prod. 79(6):1619-27 2016
Li P, AnandhiSenthilkumar H, Wu SB, Liu B, Guo ZY, Fata JE, Kennelly EJ, Long CL. Comparative UPLC-QTOF-MS-based metabolomics and bioactivities analyses of Garcinia oblongifolia. J Chromatogr B Analyt Technol Biomed Life Sci. 1011:179-95 2016
Castellanos MR, Szerszen A, Gundry S, Pirog EC, Maiman M, Rajupet S, Gomez JP, Davidov A, Debata PR, Banerjee P, Fata JE. Diagnostic imaging of cervical intraepithelial neoplasia based on hematoxylin and eosin fluorescence. Diagn Pathol. 10:119. 2015
Leonoudakis D, Huang GE, Akhavan A, Fata JE, Singh M, Gray JW, Muschler J. Endocytic trafficking of laminin is controlled by dystroglycan and disrupted in cancers. Journal of Cell Science 127:4894-903, 2014.
Jenkins EC, Debnath S, Varriano S, Gundry S, Fata JE. NHE1 Function is Necessary for Maintaining Mammary Tissue Architecture. Developmental Dynamics 243:229-242, 2014.
Debnath S, Saloum D, Dolai S, Sun C, Averick S, Raja K, Fata JE. Dendrimer-curcumin conjugate: A water soluble and effective cytotoxic agent against breast cancer cell lines. Anticancer Agents Med. Chem. 13: 1531-1539, 2013.
Bascom JL, Radisky DC, Koh E, Fata JE, Lo A, Mori H, Roosta N, Hirai Y, Bissell MJ. Epimorphin is a novel regulator of the progesterone receptor isoform-a. Cancer Res. 73(18):5719-29 2013
Sun C, Nirmalananda S, Jenkins CE., Debnath S, Balambika R, Fata JE, Raja KS. First Ayurvedic Approach towards Green Drugs: Anti Cervical Cancer-Cell Properties of Clerodendrum viscosum Root Extract. Anticancer Agents Med. Chem. 13: 1469-1476, 2013.
Priya Ranjan Debata, Mario Castellanos, Fata JE, Sara Baggett, Sritha Rajupet, Anita Szerszen, Sultana Begum, Anita Mata, Vundavalli V. Murty, Lynne M. Opitz, and Probal Banerjee. A Novel Curcumin-based Vaginal Cream Vacurin Selectively Eliminates Apposed Human Cervical Cancer Cells. Gynecol Oncol. S0090-8258: (12) 00952-3 2012.
Jenkins EC, Debnath S, Gundry S, Gundry SD, Uyar U, Fata JE. Intracellular pH regulation by Na+/H+ exchanger-1 (NHE1) is required for growth factor-induced mammary branching morphogenesis. Developmental Biology 365:71-81, 2012.
Fata JE^, Debnath S, Jenkins EC, Fournier M. Nongenomic Regulation of PTEN. Invited review for Int. J. Cell Biol. 2012:379685.
Levano K, Punia V, Raghunath M, Debata P, Curcio G, Mogha A, Purkayastha S, McCloskey D, Fata JE, Banerjee P. Atp8a1 Deficiency is Associated with Phosphatidylserine Externalization in Hippocampus and Delayed Hippocampus-Dependent Learning. Journal of Neurochemistry, 120:302-313, 2011
Andersen K, Mori H, Fata JE, Øyjord T, Mælandsmo G, Bissell MJ. The role of S100A4 in mammary gland branching morphogenesis. Developmental Biology,352:181-190, 2010.
Leonoudakis D, Singh M, Mohajer R, Mohajer P, Fata JE,. Campbell KP, Muschler JL. Dystroglycan modulates signaling of multiple hormones through control of STAT5 activity. J. Cell Science, 123:3683-3692, 2010.
Fournier M, Fata JE, Martin K, Yaswen P, Bissell MJ. Interaction of E-cadherin and PTEN regulates morphogenesis and growth arrest in human mammary epithelial cells. Cancer Research, 69:4545-4552, 2009.
Oppizzi ML, Akhavan A, Singh M, Fata JE, Muschler JL. Nuclear translocation of beta-Dystrogylcan reveals a distinctive trafficking pattern of autoproteolyzed mucins. Traffic 9:2063-2072, 2008.
Fata JE, Mori H, Ewald A, Zhang H, Yao E, Werb Z, Bissell MJ. The MAPKERK-1,2 pathway integrates distinct and antagonistic signals from TGF-alpha and FGF7 in morphogenesis of mouse mammary epithelium. Developmental Biology 306:193-207, 2007.
Fata JE*, Wood GA*, Watson KLM, and Khokha R. T. Circulating hormones and estrous stage dictate different cyclical cellular and stromal changes in murine uterus. *Contributed equally. Reproduction 133:1035-1044, 2007.
Hojilla CV, Kim I, Kassiri Z, Fata JE, Fang H, Khokha R Metalloproteinase axes increases b-catenin signaling in primary mouse mammary epithelial cells lacking TIMP3. J. Cell Science 120:1050-1060, 2007.
Liu H, Radisky D, Nelson CL, Zhang H, Fata JE, Roth R, Bissell MJ, Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a pro-tumorigenic role for TSC2. PNAS 103:4134-4139, 2006.
Bascom JL, Fata JE, Hirai Y, Sternlicht MD, Bissell MJ. Epimorphin overexpression in the mouse mammary gland promotes alveolar hyperplasia and mammary adenocarcinoma. Overexpression of epimorphin induces mammary tumorigenesis. Cancer Res. 65:8617-8621, 2005.
Radisky DC, Levy D, Littlepage L, Liu H, Nelson CM, Fata JE, Leake D, Godden EL, Albertson M, Nieto NA, Werb Z, Bissell MJ. MMP-3-induced Rac1b stimulates epithelial-mesenchymal transition and genomic instability. Nature 436:123-127, 2005. Selected commentary on this manuscript: Bussell K. Cancer: A bad influence, Nat. Rev. Mol. Cell Biol., 6:596 (2005).
Grant M, Anthony Hunt C, Xia L, Fata JE, Bissell MJ. Modeling mammary gland morphogenesis as a reaction-diffusion process. Eng. Med Biol. Soc. 1:679-682 2004.
Fata JE, Werb Z, Bissell MJ. Regulation of mammary gland branching morphogenesis by extracellular matrix and its remodeling enzymes. Breast Cancer Res. 6:1-11, 2003.
Liu J, Tsao MS, Pagura M, Shalinsky DR, Khokha R, Fata J, Johnston MR. Early combined treatment with carboplatin and the MMP inhibitor, prinomastat, prolongs survival and reduces systemic metastasis in an aggressive orthotopic lung cancer model. Lung Cancer 42:335-344, 2003.
Moorehead RA, Hojilla CV, De Belle I, Wood GA, Fata JE, Adamson ED, Watson KL, Edwards DR, Khokha R. IGF-II regulates PTEN expression in the mammary gland. J. Biol. Chem. 278:50422-50427, 2003.
Fata JE, Leco KJ, Voura E, Yu H-Y, Moorehead RA, Waterhouse P, Murphy G, and Khokha R. Accelerated apoptosis in TIMP-3 deficient mammary glands. J. Clin. Invest. 108:831-841, 2001. Selected commentary on this manuscript: The Impish Timp:the tissue inhibitor of metalloproteinase-3. Woessner JF. 108:799-800, J. Clin. Invest. 2001.
Fata JE, Chaudhary V, Khokha R. Cellular turnover in the mammary gland is correlated with systemic levels of progesterone and not 17-b-estradiol during the estrous cycle. Biol. Reprod. 65:680-688, 2001.
Moorehead R, Fata JE, Johnson M, Khokha R. Inhibition of mammary epithelial apoptosis through sustained phosphorylation of Akt/PKB in MMTV-IGF-II transgenic mice. Cell Death and Differ. 8:16-29, 2001.
Fata* JE, Kong* YY, Li J, Sasaki T, Ilie-Sasaki J, Moorehead RA, Elliott R, Scully S, Voura EB, Lacey DL, Boyle WJ, Khokha R, Penninger JM. The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. *Contributed equally. Cell 103:41-50, 2000. Selected commentary on this manuscript: Receptor activator of nuclear factor kappa-B ligand (RANKL): another link between breast and bone. Martin TJ and Gillespie MT. Trends in Endocrinology 12:2-4, 2000.
Granovsky M, Fata J, Pawling J, Muller WJ, Khokha R, Dennis JW. Suppression of tumor growth and metastasis in Mgat5-deficient mice. Nature Medicine 6:306-312, 2000. Selected commentary on this manuscript: Metastases: The glycan connection. Couldrey C and Green JE. 2:321-322, Breast Cancer Research 2000.
Sasaki T, Irie-Sasaki J, Horie Y, Bachmaier K, Fata JE, Li M, Suzuki A, Bouchard D, Ho A, Redston M, Gallinger S, Khokha R, Mak TW, Hawkins PT, Stephens L, Scherer SW, Tsao M, Penninger JM Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kg. Nature 406:897-902, 2000. See also Corrigendum Nature, 2003.
Fata JE, Ho A, Leco KJ, Moorehead RA, Khokha R. Cellular turnover and extracellular matrix remodeling in female reproductive tissues: Functions of metalloproteinases and their inhibitors. All authors contributed equally. Cellular and Molecular Life Sciences 57:77-95, 2000.
Fata JE, Leco KJ, Moorehead RA, Martin DC, Khokha R. Timp-1 is important for epithelial proliferation and branching morphogenesis during mouse mammary development. Developmental Biology 211:238-254, 1999.
Kruger A, Sanchez-Sweatman OH, Martin DC, Fata JE, Ho A, Orr FW, Ruther U, Khokha R. Host Timp-1 overexpression confers resistance to experimental brain metastasis of a fibrosarcoma cell line. Oncogene 16:2419-2423, 1998.
Kruger A, Fata JE, Khokha R. Altered tumor growth and metastasis of a T-cell lymphoma in Timp-1 transgenic mice. Blood 90:1993-2000, 1997.
Khokha R, Martin DC, Fata JE. Utilization of transgenic mice in the study of matrix degrading proteinases and their inhibitors. Cancer and Metastasis Reviews 14:97-111, 1995.
